FACTS ABOUT HOW NAD+ CONTRIBUTES TO CELL REGENERATION AND REPAIR REVEALED

Next, we taken care of cells with different concentrations of NAD+. When added for twenty-four h at eighty µM in HeLa and four hundred µM in U2OS cells, NAD+ impaired the incorporation of EdU (Fig. 2a and Extended Details Fig. 1k,l). Additionally, sixteen µM of NAD+ was sufficient to scale back fork velocity by ~forty% in HeLa cells with